Article

<i>Atrx</i> deletion impairs cGAS-STING signaling and increases response to radiation and oncolytic herpesvirus in sarcoma

2021-03-08

Abstract excerpt

ATRX is one of the most frequently altered genes in solid tumors, and mutation is especially frequent in soft tissue sarcomas. However, the role of ATRX in tumor development and response to cancer therapies remains poorly understood. Here, we developed a primary mouse model of soft tissue sarcoma and showed that Atrx deleted tumors are more sensitive to radiation therapy. In the absence of Atrx , irradiated sar...

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Literature Corpus work: 21f4b490-0671-5eef-ab57-f2a478f8d4be
DOI: 10.1101/2021.03.08.434225

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