Article

Localised stabilisation of a bistable switch for minimal-kernel phenotype control in a Boolean breast-cancer network

2026-06-24

Abstract excerpt

We pose breast-cancer therapy as a control problem on a Boolean network of signalling pathways. The goal is a minimal, druggable intervention that drives the network to apoptosis as a genuine fixed point of the free dynamics, with no node held on by force. On a 141-node network, adapted substantially from Taoma et al. with changes to its feedback wiring, a capped, no-forcing whole-network controller shows that the...

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Literature Corpus work: a8df04fc-9614-52f3-a8d7-d75b9d23ad0b
DOI: 10.64898/2026.06.18.733086

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