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Article

Uncovering minimal control of cell fate by natural dynamics.

Proceedings of the National Academy of Sciences of the United States of America - 22 Sept 2026

Brahmana Ferio, Hopper Corbin, Lee Woojeong, Cho Kwang-Hyun

Abstract excerpt

It is crucial to identify cues that induce cell fate transitions for applications ranging from cell therapy to drug discovery. Computational analysis of logical models of gene regulatory networks can identify such cues, which can then be used by control strategies to direct cell fate. However, current control strategies emphasize permanent interventions that cripple natural regulatory responses, undermining...

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Topics

Myocytes, Cardiac
Animals
Gene Regulatory Networks
Cell Differentiation
Humans
Mast Cells
Models, Biological

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Macrophages

Regeneration

Phenotype

Source

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Identifiers

PMID: 42735313
DOI: 10.1073/pnas.2604777123
PMCID: PMC13598151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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