Article

Precision Therapeutics in Triple-Negative Breast Cancer: Boolean Network Control and Pharmacological Mapping of Individualized Models

2026-07-10

Abstract excerpt

Triple-negative Breast cancer is a highly heterogeneous tumor subtype lacking universal therapeutic targets, a factor that frequently renders standard pharmacological approaches ineffective. To address the urgent clinical need for precision strategies, we developed a computational framework centered on personalization. Utilizing specific gene expression data, we initially constructed and calibrated 41 individualiz...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e70f3703-9c98-5b50-bf24-5dec752f7caa
DOI: 10.20944/preprints202607.0768.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Precision Therapeutics in Triple-Negative Breast Cancer: Boolean Network Control and Pharmacological Mapping of Individualized ModelsDOI 10.20944/preprints202607.0768.v1Read

OPTIMIZING THERAPEUTIC TARGETS FOR BREAST CANCER USING BOOLEAN NETWORK MODELSSemantic proximity Read

From Pathway to Patient: Molecular Dysregulation as Basis for Minimal Sequential Intervention Strategy in Basal-Like Breast CancerSemantic proximity Read

Hybrid Computational Modeling with Multi-Level Validation Identifies TK1-VIM as a Robust Therapeutic Pair in Triple-Negative Breast CancerSemantic proximity Read

Drug Target Identification in Triple Negative Breast Cancer Stem Cell Pathways: A Computational Study of Gene Regulatory Pathways Using Boolean NetworksSemantic proximity Read

Drug Target Identification in Triple Negative Breast Cancer Stem Cell Pathways: a computational study of gene regulatory pathways using Boolean networksSemantic proximity Read

Identification of Therapeutic Gene Targets in Triple-Negative Breast Cancer: A Hybrid Approach Integrating Semidefinite Programming, Boolean Simulation, and Druggability AnalysisSemantic proximity Read

Conquering the challenges of genotypic and phenotypic tumor heterogeneity to realize the promise of personalized cancer therapy: the role of academia.Semantic proximity Read

Single-cell-guided identification of logic-gated antigen combinations for designing effective and safe CAR therapySemantic proximity Read

The Landscape of Receptor-Mediated Precision Cancer Combination Therapy: A Single-Cell PerspectiveSemantic proximity Read

Cell Line–Specific Network Models of ER+ Breast Cancer Identify Potential PI3Kα Inhibitor Resistance Mechanisms and Drug CombinationsSemantic proximity Read

Localised stabilisation of a bistable switch for minimal-kernel phenotype control in a Boolean breast-cancer networkSemantic proximity Read