Article
A Dynamic Boolean Model of the Mammalian Cell Cycle: Enhanced Robustness and Mutational Analysis.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2026
Alsharaiah Mohammad Abdallah, Samarasinghe Sandhya, Kulasiri Don
Abstract excerpt
The mammalian cell cycle is a tightly regulated process driven by cyclins, their regulators. While previous Boolean models captured certain aspects of cell cycle dynamics, they suffered from incomplete coverage of key regulatory proteins and limited temporal realism. Here, we present an improved Boolean model of the mammalian cell cycle core control system. The model incorporates a complete set of 13 essential...
Read the complete abstract on PubMedTopics
- Cell Cycle
- Animals
- Models, Biological
- Humans
- Mutation
- Computer Simulation
- Cyclins