Article

Crystallizing the Parkinson’s Disease Protein LRRK2 Under Microgravity Conditions

2018-02-04

Abstract excerpt

Mutations in the gene coding for leucine-rich repeat kinase 2 (LRRK2) are a considerable cause for Parkinson’s disease (PD). However, the high- resolution 3D structure of the protein is still lacking. This structure will not only help to understand PD etiology but will also enable rational drug design. We have established a reliable method to produce LRRK2 crystals for the first time. However, the limited resoluti...

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Literature Corpus work: a8b1257e-2f06-5911-aabf-88cfd1cf7b1b
DOI: 10.1101/259655

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