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Article

From structure to ætiology: a new window on the biology of leucine-rich repeat kinase 2 and Parkinson's disease.

The Biochemical journal - 30 Jul 2021

Herbst Susanne, Lewis Patrick A

Abstract excerpt

Since the discovery of mutations in leucine-rich repeat kinase 2 (LRRK2) as an underlying genetic cause for the development of Parkinson's disease (PD) in 2004 (Neuron 44, 601-607; Neuron 44, 595-600), and subsequent efforts to develop LRRK2 kinase inhibitors as a therapy for Parkinson's (Expert Opin. Ther. Targets 21, 751-753), elucidating the atomic resolution structure of LRRK2 has been a major goal of...

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Identifiers

PMID: 34328508
DOI: 10.1042/BCJ20210383
PMCID: PMC8331089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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