Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

O6-Methylguanine-DNA methyltransferase inactivation and chemotherapy

1 Feb 2008

Abstract excerpt

INTRODUCTION: Alkylating agents are frequently used in the chemotherapy of many types of cancer. This group of drugs mediates cell death by damaging DNA and therefore, understandably, cellular DNA repair mechanisms can influence both their antitumour efficacy and their dose-limiting toxicities. SOURCES OF DATA: This review focuses on the mechanism of action of the DNA repair protein, O(6)-methylguanine-DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18245773
DOI: 10.1093/bmb/ldm036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

O6-Methylguanine-DNA methyltransferase inactivation and chemotherapyPMID 18245773Read ↗

MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents.Semantic proximity Read ↗

The therapeutic potential ofO6-alkylguanine DNA alkyltransferase inhibitorsSemantic proximity Read ↗

The dual role of DNA repair protein MGMT in cancer prevention and treatmentSemantic proximity Read ↗

Clinical Relevance of <i>MGMT</i> in the Treatment of CancerSemantic proximity Read ↗

Targeted Modulation of MGMT: Clinical ImplicationsSemantic proximity Read ↗

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.Semantic proximity Read ↗

Correlation of O<sup>6</sup>-Methylguanine Methyltransferase (MGMT) Promoter Methylation With Clinical Outcomes in Glioblastoma and Clinical Strategies to Modulate MGMT ActivitySemantic proximity Read ↗

S-alkylthiolation of O6-methylguanine-DNA-methyltransferase (MGMT) to sensitize cancer cells to anticancer therapy.Semantic proximity Read ↗

Role of Mismatch Repair and MGMT in Response to Anticancer TherapiesSemantic proximity Read ↗

O6-Methylguanine-DNA Methyltransferase (MGMT): Challenges and New Opportunities in Glioma ChemotherapySemantic proximity Read ↗

Regulation of expression of O6-methylguanine-DNA methyltransferase and the treatment of glioblastoma (Review)Semantic proximity Read ↗

Mechanisms of carcinogenicity/chemotherapy by O6-methylguanineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.