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Article

Genetic chemoprotection with mutant O6-alkylguanine-DNA-alkyltransferases.

Current gene therapy - 1 Feb 2002

Hobin D A, Fairbairn L J

Abstract excerpt

One of the main barriers to more efficacious use of modern chemotherapeutic agents, is the collateral toxicity exhibited in normal, highly proliferative tissues, primarily the haemopoietic, gastrointestinal and pulmonary tissues. Drug resistance of tumours to these drugs compounds this problem. This review discusses the role of O6-alkylguanine-DNA alkyltransferase (ATase) in conferring protection against...

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Identifiers

PMID: 12108970
DOI: 10.2174/1566523023348255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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