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Article

Temozolomide: Mechanisms of Action, Repair and Resistance

2012-01-01

Abstract excerpt

Glioblastoma multiforme is the most common aggressive adult primary tumour of the central nervous system. Treatment includes surgery, radiotherapy and adjuvant temozolomide (TMZ) chemotherapy. TMZ is an alkylating agent prodrug, delivering a methyl group to purine bases of DNA (O6-guanine; N7-guanine and N3-adenine). The primary cytotoxic lesion, O6-methylguanine (O6-MeG) can be removed by methylguanine methyltran...

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Literature Corpus work
268b272c-bbdd-597b-be88-841968fc6b31
DOI
10.2174/1874-470211205010102
Open publication

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Temozolomide: Mechanisms of Action, Repair and ResistanceDOI 10.2174/1874-470211205010102
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