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Virulence in Pectobacterium atrosepticum is regulated by a coincidence circuit involving quorum sensing and the stress alarmone, (p)ppGpp.

Molecular microbiology - 1 Nov 2013

Bowden Steven D, Eyres Alison, Chung Jade C S, Monson Rita E, Thompson Arthur, Salmond George P C, Spring David R, Welch Martin

Abstract excerpt

Pectobacterium atrosepticum (Pca) is a Gram-negative phytopathogen which causes disease by secreting plant cell wall degrading exoenzymes (PCWDEs). Previous studies have shown that PCWDE production is regulated by (i) the intercellular quorum sensing (QS) signal molecule, 3-oxo-hexanoyl-l-homoserine lactone (OHHL), and (ii) the intracellular 'alarmone', (p)ppGpp, which reports on nutrient limitation. Here we show...

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PMID: 23957692
DOI: 10.1111/mmi.12369

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