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Dextromethorphan inhibits collagen transport in the endoplasmic reticulum eliciting an anti-fibrotic response in <i>ex-vivo</i> and <i>in vitro</i> models of pulmonary fibrosis

2023-04-19

Abstract excerpt

Excessive deposition of fibrillar collagen in the interstitial extracellular matrix (ECM) of human lung tissue causes fibrosis, which can ultimately lead to organ failure. Despite our understanding of the molecular mechanisms underlying the disease, a cure for pulmonary fibrosis has not yet been found. In this study, we screened an FDA-approved drug library containing 712 drugs and found that Dextromethorphan (DXM...

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Literature Corpus work
a88c4abd-c58e-520d-a0f0-4795627adee3
DOI
10.1101/2023.04.19.537530
Open publication

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Dextromethorphan inhibits collagen transport in the endoplasmic reticulum eliciting an anti-fibrotic response in <i>ex-vivo</i> and <i>in vitro</i> models of pulmonary fibrosisDOI 10.1101/2023.04.19.537530
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