CDDO-Imidazole regulates RBC alloimmunization to the KEL antigen by activating Nrf2

Abstract excerpt

During red blood cell (RBC) transfusion, production of alloantibodies can promote significant hemolytic events. However, most transfusion recipients do not form anti-RBC alloantibodies. Identifying mechanisms that inhibit alloimmunization may lead to prophylactic interventions. One potential regulatory mechanism is activation of the transcription factor, nuclear factor erythroid-derived 2-like 2 (Nrf2), a master r...

Topics

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• Anemia, Hemolytic, Autoimmune
• Cell Size
• Hemolysis
• Hydrogen Peroxide
• NF-E2-Related Factor 2
• Response Elements
• Splenomegaly
• Tooth

Identifiers and source

Literature Corpus work

98293693-786b-5838-9879-6bb648a91f93

DOI

10.1101/2025.04.03.645598