Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of substrate stiffness on pulmonary fibroblast activation by TGF-β.

Acta biomaterialia - 1 Jul 2012

Chia H N, Vigen M, Kasko A M

Abstract excerpt

Peptide crosslinkers containing the sequence C-X-CG (X represents various adhesive peptides) were incorporated into poly(ethylene glycol) (PEG) hydrogel networks with different mechanical properties. Pulmonary fibroblasts (PFs) exhibit increased adhesion to rigid hydrogels modified with X=RGDS, DGEA and IKVAV (0.5 and/or 5 mM) compared with a scrambled control (X=HRPNS). PFs exhibit increased adhesion to softer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Adsorption
Share to Cell Adhesion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Communication

Share to Cell Count

Share to Polyethylene Glycols

Share to Stress, Mechanical

Share to Transforming Growth Factor beta1

Source

Identifiers

PMID: 22446029
DOI: 10.1016/j.actbio.2012.03.027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of substrate stiffness on pulmonary fibroblast activation by TGF-β.PMID 22446029Read ↗

Progressive matrix stiffening of tyramine-modified silk fibroin hydrogels governs stage-specific pulmonary fibroblast activationSemantic proximity Read ↗

The combined influence of viscoelasticity and adhesive cues on fibroblast spreading and focal adhesion formationSemantic proximity Read ↗

Dynamically stiffening biomaterials reveal age- and sex-specific differences in pulmonary arterial adventitial fibroblast activationSemantic proximity Read ↗

Dynamically stiffening biomaterials reveal age- and sex-specific differences in pulmonary arterial adventitial fibroblast activationSemantic proximity Read ↗

Hydrogel mechanics regulate fibroblast DNA methylation and chromatin condensationSemantic proximity Read ↗

In situ elasticity modulation with dynamic substrates to direct cell phenotype.Semantic proximity Read ↗

3D matrix stiffness modulation unveils cardiac fibroblast phenotypic switching.Semantic proximity Read ↗

N-cadherin Adhesive Interactions Mechanically Modulate Phenotype of Pancreatic Stellate Cells via YAP-dependent Mechanosensing.Semantic proximity Read ↗

Substrate stiffness modulates cardiac fibroblast activation, senescence, and proinflammatory secretory phenotype.Semantic proximity Read ↗

Dynamic stiffening of poly(ethylene glycol)-based hydrogels to direct valvular interstitial cell phenotype in a three-dimensional environment.Semantic proximity Read ↗

Substrate stiffness modulates integrin α5 expression and ECM-associated gene expression in fibroblastsSemantic proximity Read ↗

Physical and chemical microenvironmental cues orthogonally control the degree and duration of fibrosis-associated epithelial-to-mesenchymal transitions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.