Article

Untangling the mechanisms of pulmonary hypertension-induced right ventricular stiffening in a large animal model

2023-04-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Pulmonary arterial hypertension (PHT) is a devastating disease with low survival rates. In PHT, chronic pressure overload leads to right ventricle (RV) remodeling and stiffening; thus, impeding diastolic filling and ventricular function. Multiple mechanisms contribute to RV stiffening, including wall thickening, microstructural disorganization, and myocardial stiffening. The...

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Literature Corpus work: 395fb3a4-1620-5700-8a26-6d0be7832ccf
DOI: 10.1101/2023.04.03.535491

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