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Article

SARM1 knockout does not rescue neuromuscular phenotypes in a Charcot-Marie-Tooth disease Type 1A mouse model.

Journal of the peripheral nervous system : JPNS - 1 Mar 2022

Moss Kathryn R, Johnson Anna E, Bopp Taylor S, Yu Andrew T, Perry Ken, Chung Tae, Höke Ahmet

Abstract excerpt

Charcot-Marie-Tooth disease Type 1A (CMT1A) is caused by duplication of the PMP22 gene and is the most common inherited peripheral neuropathy. Although CMT1A is a dysmyelinating peripheral neuropathy, secondary axon degeneration has been suggested to drive functional deficits in patients. Given that SARM1 knockout is a potent inhibitor of the programmed axon degeneration pathway, we asked whether SARM1 knockout...

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Identifiers

PMID: 35137510
DOI: 10.1111/jns.12483
PMCID: PMC8940700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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