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Article

ES-62 suppression of arthritis reflects epigenetic rewiring of synovial fibroblasts to a joint-protective phenotype

2020-10-08

Abstract excerpt

The parasitic worm product, ES-62 protects against collagen-induced arthritis, a mouse model of rheumatoid arthritis (RA) by suppressing the synovial fibroblast (SF) responses perpetuating inflammation and driving joint destruction. Such SF responses are shaped during disease progression by the inflammatory microenvironment of the joint that promotes remodelling of their epigenetic landscape, inducing an “aggressi...

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Identifiers and source

Literature Corpus work
a80f8b7b-9c5e-5339-8dc3-43811eb4d7a2
DOI
10.1101/2020.10.08.331942
Open publication

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ES-62 suppression of arthritis reflects epigenetic rewiring of synovial fibroblasts to a joint-protective phenotypeDOI 10.1101/2020.10.08.331942
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