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A secreted helminth microRNA suppresses gastrointestinal cell differentiation required for innate immunity

27 Mar 2025

Abstract excerpt

Pathogens have developed multiple strategies to modulate host immune defense mechanisms. Understanding how this is achieved has potential to inform novel therapeutics for diseases caused by immune dysfunction. Parasitic helminths are masters of immune evasion, via release of secreted products, resulting in chronic infection. Helminths secrete small regulatory microRNA (miRNAs), which can interact with host cells....

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PMID: 40213548
DOI: 10.3389/fimmu.2025.1558132

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