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Cytokines from parasites: manipulating host responses by molecular mimicry

29 Apr 2025

Abstract excerpt

Helminth parasites have evolved sophisticated methods for manipulating the host immune response to ensure long-term survival in their chosen niche, for example, by secreting products that interfere with the host cytokine network. Studies on the secretions of Heligmosomoides polygyrus have identified a family of transforming growth factor-β (TGF-β) mimics (TGMs), which bear no primary amino acid sequence...

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PMID: 40302223
DOI: 10.1042/bcj20253061

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