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Article

Does rheumatoid arthritis represent an adaptive, thrifty condition?

Medical hypotheses - 1 Jan 2010

Reser Jared E, Reser William W

Abstract excerpt

The present article presents epidemiological, and comparative evidence supporting the hypothesis that rheumatoid arthritis (RA) may represent a thrifty adaptation selected to compel animals to minimize voluntary energy expenditure. The autoimmune, pathophysiological manifestations underlying RA are framed here as constituting an evolved, protective mechanism that would have influenced animals to avoid exertion...

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Identifiers

PMID: 19716239
DOI: 10.1016/j.mehy.2009.07.041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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