Article
Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-specific Immune Changes
2018-01-27
Abstract excerpt
Epigenetic mechanisms, like DNA methylation, determine immune cell phenotype. To understand the epigenetic alterations induced by helminth co-infections, we evaluated the longitudinal effect of ascariasis and schistosomiasis infection on CD4+ T cell DNA methylation and the downstream tuberculosis (TB)-specific and BCG-induced immune phenotype. All experiments were performed on human primary immune cells from a lon...
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Identifiers and source
- Literature Corpus work
- f63fd053-58d2-5b56-b288-586c941b0d29
- DOI
- 10.1101/255125