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Combined targeted and epigenetic-based therapy enhances antitumor immunity by stabilizing GATA6-dependent MHCI expression in pancreatic ductal adenocarcinoma

2024-06-17

Abstract excerpt

<title>Abstract</title> <p>Intratumoral heterogeneity underlies therapeutic resistance in pancreatic ductal adenocarcinoma (PDAC). GATA6 plays pivotal role in regulating tumor cell plasticity in the classical subtype of PDAC. Here we investigated the immune features of GATA6+ tumor cells and exploited targeting strategies to enhance GATA6-dependent anti-tumor immune responses using preclinical PDAC models. Our fi...

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Literature Corpus work
a805cc7b-608b-5f6b-8da0-77ddc5c70e08
DOI
10.21203/rs.3.rs-4555029/v1
Open publication

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Combined targeted and epigenetic-based therapy enhances antitumor immunity by stabilizing GATA6-dependent MHCI expression in pancreatic ductal adenocarcinomaDOI 10.21203/rs.3.rs-4555029/v1
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