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Article

Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response in pancreatic cancer

6 Jan 2025

Abstract excerpt

Abstract Pancreatic ductal adenocarcinoma (PDAC) displays a high degree of spatial subtype heterogeneity and co-existence, linked to a diverse microenvironment and worse clinical outcome. However, the underlying mechanisms remain unclear. Here, by combining preclinical models, multi-center clinical, transcriptomic, proteomic, and patient bioimaging data, we identify an interplay between neoplastic intrinsic AP1...

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Share to Epigenetics and DNA Methylation
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PMID: 39762215
DOI: 10.1038/s41467-024-55330-7

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