Article

Cell type-specific disruption of cortico-striatal circuitry drives repetitive patterns of behaviour in fragile X syndrome model mice

2022-12-08

Abstract excerpt

<h4>Summary</h4> Individuals with fragile X syndrome (FXS) are frequently diagnosed with autism spectrum disorder (ASD), including increased risk for restricted and repetitive behaviours (RRBs). Consistent with observations in humans, FXS model mice display distinct RRBs and hyperactivity that are consistent with dysfunctional cortico-striatal circuits, an area relatively unexplored in FXS. Using a multidisciplin...

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Literature Corpus work: a7fbcb73-1b25-565b-b5c6-78ac32d3fc75
DOI: 10.1101/2022.12.08.519509

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