Article

Disruption of Cell-Type-Specific Molecular Programs of Medium Spiny Neurons in Autism

2025-11-07

Abstract excerpt

Autism spectrum disorders (ASD) are highly heritable neurodevelopmental conditions with major contributions from rare genetic variants. Most studies have focused on cortical mechanisms; even growing evidence implicates subcortical circuits in ASD etiology. To systematically map developmental and molecular alterations beyond the cortex, we profiled lineage relationships across five brain regions in an ASD mouse mod...

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Literature Corpus work: 6ff6e4da-d4fc-575f-bbcf-b01c359d1def
DOI: 10.1101/2025.11.05.686845

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