Article
Balancing selection on a regulatory region exhibiting ancient variation that predates human-neandertal divergence.
PLoS genetics - 1 Apr 2013
Gokcumen Omer, Zhu Qihui, Mulder Lubbertus C F, Iskow Rebecca C, Austermann Christian, Scharer Christopher D, Raj Towfique, Boss Jeremy M, Sunyaev Shamil, Price Alkes, Stranger Barbara, Simon Viviana, Lee Charles
Abstract excerpt
Ancient population structure shaping contemporary genetic variation has been recently appreciated and has important implications regarding our understanding of the structure of modern human genomes. We identified a ∼36-kb DNA segment in the human genome that displays an ancient substructure. The variation at this locus exists primarily as two highly divergent haplogroups. One of these haplogroups (the NE1...
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