Article

Spt5 interacts genetically with Myc and is limiting for brain tumor growth in Drosophila

2023-04-17

Abstract excerpt

The transcription factor SPT5 physically interacts with MYC oncoproteins and is essential for efficient transcriptional activation of MYC targets in cultured cells. Here we use Drosophila to address the relevance of this interaction in a living organism. Spt5 displays moderate synergy with Myc in fast proliferating young imaginal disc cells. During later development, Spt5-knockdown has no detectable consequences...

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Literature Corpus work: a7c3586c-8dd8-58cd-8f3a-11c2ac641bcb
DOI: 10.1101/2023.04.14.536839

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