Article

A potent alpaca-derived nanobody that neutralizes SARS-CoV-2 variants

2022-01-20

Abstract excerpt

The spike glycoprotein of SARS-CoV-2 engages with human angiotensin-converting enzyme 2 (ACE2) to facilitate infection. Here, we describe an alpaca-derived heavy chain antibody fragment (VHH), saRBD-1, that disrupts this interaction by competitively binding to the spike protein receptor-binding domain. We further generated an engineered bivalent nanobody construct engineered by a flexible linker, and a dimeric Fc...

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Literature Corpus work: a7c2ccbb-cc21-500d-9f62-9bb33a407285
DOI: 10.1101/2022.01.18.476801

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