Article

Broad neutralizing nanobody against SARS-CoV-2 engineered from pre-designed synthetic library

2021-08-09

Abstract excerpt

SARS-CoV-2 infection is initiated with Spike glycoprotein binding to the receptor of human angiotensin converting enzyme 2 via its receptor binding domain. Blocking this interaction is considered as an effective approach to inhibit virus infection. Here we report the discovery of a neutralizing nanobody, VHH60, directly produced from a humanized synthetic nanobody library. VHH60 competes with human ACE2 to bind th...

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Literature Corpus work: 716ce82f-93a2-5a34-a654-8fe6295482b1
DOI: 10.1101/2021.08.07.455523

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