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A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo

10 Jan 2022

Abstract excerpt

Antibodies binding to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike have therapeutic promise, but emerging variants show the potential for virus escape. This emphasizes the need for therapeutic molecules with distinct and novel neutralization mechanisms. Here we describe the isolation of a nanobody that interacts simultaneously with two RBDs from different spike trimers of SARS-CoV-2,...

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Share to Advanced biosensing and bioanalysis techniques
Share to Bacteriophages and microbial interactions
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PMID: 35013189
DOI: 10.1038/s41467-021-27610-z

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