Article

A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 <i>in vivo</i>

2021-03-21

Abstract excerpt

Antibodies binding to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike have therapeutic promise, but emerging variants show the potential for virus escape. This emphasizes the need for therapeutic molecules with distinct and novel neutralization mechanisms. Here we isolated a nanobody that interacts simultaneously with two RBDs from different spike trimers of SARS-CoV-2, rapidly inducing the...

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Literature Corpus work: d8b549e5-9e02-5965-a536-6662874412a4
DOI: 10.1101/2021.03.20.436243

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