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Article

Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells

26 Sept 2012

Abstract excerpt

AIMS/HYPOTHESIS: Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hIPSCs) offer unique opportunities for regenerative medicine and for the study of mammalian development. However, developing methods to differentiate hESCs/hIPSCs into specific cell types following a natural pathway of development remains a major challenge. METHODS: We used defined culture media to identify signalling...

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PMID: 23011350
DOI: 10.1007/s00125-012-2687-x

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