Article

Polygenic Background Contributes to GCK-MODY Clinical Presentation and Glycaemic Variability

2025-08-08

Abstract excerpt

<h4>Aims/Hypothesis</h4> GCK-MODY (Glucokinase-Maturity Onset Diabetes of the Young) causes lifelong, mild hyperglycaemia with high penetrance. Variation in glycaemic phenotype among carriers remains unexplained. We hypothesised that polygenic background contributes to this variability. <h4>Methods</h4> To test whether polygenic background contributes to the GCK-MODY clinical phenotype, we analysed polygenic ris...

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Literature Corpus work: a7c0f2e2-66d4-5139-9490-223649f8a203
DOI: 10.1101/2025.08.04.25332935

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