Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A polygenic risk score derived from common variants of monogenic diabetes genes is associated with young-onset type 2 diabetes and cardiovascular-kidney complications.

Diabetologia - 1 Feb 2025

O Chun-Kwan, Fan Baoqi, Tsoi Sandra T F, Tam Claudia H T, Wan Raymond, Lau Eric S H, Shi Mai, Lim Cadmon K P, Yu Gechang, Ho Jane P Y, Chow Elaine Y K, Kong Alice P S, Ozaki Risa, So Wing Yee, Ma Ronald C W, Luk Andrea O Y, Chan Juliana C N

Abstract excerpt

AIMS/HYPOTHESIS: Monogenic diabetes is caused by rare mutations in genes usually implicated in beta cell biology. Common variants of monogenic diabetes genes (MDG) may jointly influence the risk of young-onset type 2 diabetes (YOD, diagnosed before the age of 40 years) and cardiovascular and kidney events. METHODS: Using whole-exome sequencing data, we constructed a weighted polygenic risk score (wPRS) consisting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Cardiovascular Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Cross-Sectional Studies

Share to Diabetes Mellitus, Type 2

Share to Diabetic Nephropathies

Share to Genetic Risk Score

Share to Multifactorial Inheritance

Source

Open in PubMed Open full text

Identifiers

PMID: 39579208
DOI: 10.1007/s00125-024-06320-3
PMCID: PMC11732898

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A polygenic risk score derived from common variants of monogenic diabetes genes is associated with young-onset type 2 diabetes and cardiovascular-kidney complications.PMID 39579208Read ↗

Common Genetic Variants Modify Disease Risk and Clinical Presentation in Monogenic DiabetesSemantic proximity Read ↗

A combined polygenic score of 21,293 rare and 22 common variants significantly improves diabetes diagnosis based on hemoglobin A1C levelsSemantic proximity Read ↗

Polygenic risk scores predict diabetic complications and their response to therapySemantic proximity Read ↗

Type 2 diabetes polygenic risk score demonstrates context-dependent effects and associations with type 2 diabetes-related risk factors and complications across diverse populationsSemantic proximity Read ↗

Polygenic risk score for type 2 diabetes shows context-dependent effects across populations.Semantic proximity Read ↗

Identification Of Pathogenic Mutations And Application Of Polygenic Risk Scores In Early-Onset Diabetes PatientsSemantic proximity Read ↗

Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation.Semantic proximity Read ↗

Rare variant association analysis in 51,256 type 2 diabetes cases and 370,487 controls informs the spectrum of pathogenicity of monogenic diabetes genesSemantic proximity Read ↗

Genetic and Clinical Characteristics of Monogenic Diabetes in Japan: A Nationwide Study by the Japan Diabetes Society.Semantic proximity Read ↗

Exploring the shared genetic landscape of diabetes and cardiovascular disease: findings and future implicationsSemantic proximity Read ↗

Population-Scale, Genotype-First Characterization of Monogenic Diabetes in 374,973 Multi-Ancestry Individuals from the <i>All of Us</i> Research ProgramSemantic proximity Read ↗

A clinical prediction model for beta cell monogenetic diabetes in Chinese patients with early-onset type 2 diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.