Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polygenic background contributes to GCK-MODY clinical presentation and glycaemic variability.

Diabetologia - 1 Jul 2026

Murray Leech Jacques, Arni Ankit M, Chundru V Kartik, Sharp Luke N, Colclough Kevin, Hattersley Andrew T, Weedon Michael N, Patel Kashyap A

Abstract excerpt

AIMS/HYPOTHESIS: GCK-MODY (glucokinase MODY) causes lifelong, mild hyperglycaemia with high penetrance. Variation in glycaemic phenotype among carriers remains unexplained. We hypothesised that polygenic background contributes to this variability and that this influence differs from that of HNF1A-MODY. METHODS: To test whether polygenic background contributes to the GCK-MODY clinical phenotype, we analysed...

Topics

Join the communities discussing this publication.

Blood Glucose
Diabetes Mellitus, Type 2
Genetic Predisposition to Disease
Genetic Risk Score
Glucokinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glycated Hemoglobin

Hepatocyte Nuclear Factor 1-alpha

Multifactorial Inheritance

Source

Open in PubMed Open full text

Identifiers

PMID: 41848901
DOI: 10.1007/s00125-026-06712-7
PMCID: PMC13236825

Genes

GCK
HNF1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polygenic background contributes to GCK-MODY clinical presentation and glycaemic variability.PMID 41848901Read ↗

Polygenic Background Contributes to GCK-MODY Clinical Presentation and Glycaemic VariabilitySemantic proximity Read ↗

Common Genetic Variants Modify Disease Risk and Clinical Presentation in Monogenic DiabetesSemantic proximity Read ↗

Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation.Semantic proximity Read ↗

The penetrance of age-related monogenic disease depends on ascertainment contextSemantic proximity Read ↗

Population prevalence, penetrance, and mortality for genetically confirmed MODYSemantic proximity Read ↗

Underestimated risk of secondary complications in pathogenic and glucose-elevating GCK variant carriers with type 2 diabetesSemantic proximity Read ↗

Population-Scale, Genotype-First Characterization of Monogenic Diabetes in 374,973 Multi-Ancestry Individuals from the <i>All of Us</i> Research ProgramSemantic proximity Read ↗

Identification Of Pathogenic Mutations And Application Of Polygenic Risk Scores In Early-Onset Diabetes PatientsSemantic proximity Read ↗

Identification Of Pathogenic Mutations And Application Of Polygenic Risk Scores To Differentiate MODY Patients From Other Diabetes TypesSemantic proximity Read ↗

Glucokinase-Related Maturity-Onset Diabetes of the Young in India and the Clinical Utility of the MODY Probability Calculator for Identifying Underdiagnosed and Rare FormsSemantic proximity Read ↗

Population Prevalence, Penetrance, and Mortality for Genetically Confirmed MODY.Semantic proximity Read ↗

Patients with Type 2 Diabetes and a<i>GCK</i>variant are still at risk for T2D-related secondary complicationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.