Article

Common Genetic Variants Modify Disease Risk and Clinical Presentation in Monogenic Diabetes

2025-02-21

Abstract excerpt

The contribution of polygenic background in young onset monogenic disorders needs further exploration. Understanding this will provide new biological insights and may improve risk prediction of monogenic disease. Here we investigated the role of polygenic background in MODY—a common monogenic disorder with an age-dependent onset.We found strong enrichment of type 2 diabetes (T2D) polygenic risk, but not type 1 dia...

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Literature Corpus work: d5832177-9f01-50ee-a84b-52d921ec622d
DOI: 10.1101/2025.02.19.25322524

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