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Development and validation of a novel survival model for acute myeloid leukemia based on autophagy-related genes

12 Aug 2021

Abstract excerpt

Background Acute myeloid leukemia (AML) is one of the most common blood cancers, and is characterized by impaired hematopoietic function and bone marrow (BM) failure. Under normal circumstances, autophagy may suppress tumorigenesis, however under the stressful conditions of late stage tumor growth autophagy actually protects tumor cells, so inhibiting autophagy in these cases also inhibits tumor growth and...

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PMID: 34447636
DOI: 10.7717/peerj.11968

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