Article

Polygenic risk score for ulcerative colitis predicts immune checkpoint inhibitor-mediated colitis

2023-05-16

Abstract excerpt

Immune checkpoint inhibitors (ICIs) are a remarkable advancement in cancer therapeutics; however, a substantial proportion of patients develop severe immune-related adverse events (irAEs). Understanding and predicting irAEs is a key to advancing precision immuno-oncology. Immune checkpoint inhibitor-mediated colitis (IMC) is a significant complication from ICI and can have life-threatening consequences. Based on c...

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Literature Corpus work: a7947bfe-6596-5b7a-ba88-c834f961cc33
DOI: 10.1101/2023.05.15.23289680

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