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Article

Polygenic risk and causal inference of psychiatric comorbidity in inflammatory bowel disease among patients with European ancestry.

Journal of translational medicine - 27 Jan 2022

Li Yao, Bernstein Charles N, Xu Wei, Hu Pingzhao

Abstract excerpt

BACKGROUND: Approximately 40% of persons with inflammatory bowel disease (IBD) experience psychiatric comorbidities (PC). Previous studies demonstrated the polygenetic effect on both IBD and PC. In this study, we evaluated the contribution of genetic variants to PC among the IBD population. Additionally, we evaluated whether this effect is mediated by the expression level of the RBPMS gene, which was identified...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35086532
DOI: 10.1186/s12967-022-03242-9
PMCID: PMC8793227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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