Article

Physiological levels of 3-hydroxykynurenine alter mitochondrial function and morphology in neuronal cells

2026-05-13

Abstract excerpt

Mitochondrial morphology and function are critical determinants of neuronal function and survival, with disruptions in mitochondrial dynamics often preceding the overt neuronal dysfunction seen in neurodegenerative diseases such as Alzheimer’s disease, Huntington’s disease and Parkinson’s disease. The kynurenine pathway accounts for 95% of dietary tryptophan catabolism and many of the metabolites are neuroactive,...

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Literature Corpus work: a78cc0e0-6ac7-5ce8-8080-87a31389f5fc
DOI: 10.64898/2026.05.13.724856

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