Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics.

PLoS genetics - 1 Nov 2020

Maddison Daniel C, Alfonso-Núñez Mónica, Swaih Aisha M, Breda Carlo, Campesan Susanna, Allcock Natalie, Straatman-Iwanowska Anna, Kyriacou Charalambos P, Giorgini Flaviano

Abstract excerpt

The enzyme kynurenine 3-monooxygenase (KMO) operates at a critical branch-point in the kynurenine pathway (KP), the major route of tryptophan metabolism. As the KP has been implicated in the pathogenesis of several human diseases, KMO and other enzymes that control metabolic flux through the pathway are potential therapeutic targets for these disorders. While KMO is localized to the outer mitochondrial membrane...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Dynamins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Gene Knockdown Techniques

Share to Kynurenine

Share to Mitochondrial Dynamics

Share to Mitophagy

Share to Protein Processing, Post-Translational

Source

Open in PubMed Open full text

Identifiers

PMID: 33170836
DOI: 10.1371/journal.pgen.1009129
PMCID: PMC7654755

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics.PMID 33170836Read ↗

Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency.Semantic proximity Read ↗

Full-length in meso structure and mechanism of rat kynurenine 3-monooxygenase inhibition.Semantic proximity Read ↗

Biallelic Variants in KMO Cause a Novel Form of Congenital NAD DeficiencySemantic proximity Read ↗

Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila.Semantic proximity Read ↗

Mt-Keima detects PINK1-PRKN mitophagy in vivo with greater sensitivity than mito-QCSemantic proximity Read ↗

Assessment of mitophagy in mt‐Keima Drosophila revealed an essential role of the PINK1‐Parkin pathway in mitophagy induction in vivoSemantic proximity Read ↗

Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency.Semantic proximity Read ↗

Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin.Semantic proximity Read ↗

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in DrosophilaSemantic proximity Read ↗

Modulating the Kynurenine pathway or sequestering toxic 3-hydroxykynurenine protects the retina from light induced damage in <i>Drosophila</i>Semantic proximity Read ↗

Physiological levels of 3-hydroxykynurenine alter mitochondrial function and morphology in neuronal cellsSemantic proximity Read ↗

A Drosophila model of mitochondrial disease phenotypic heterogeneity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.