Mitochondria, Oxidative Stress and the Kynurenine System, with a Focus on Ageing and Neuroprotection.

Abstract excerpt

In this review, the potential causes of ageing are discussed. We seek to gain insight into the main physiological functions of mitochondria and discuss alterations in their function and the genome, which are supposed to be the central mechanisms in senescence. We conclude by presenting the potential modulating role of the kynurenine pathway in the ageing processes. Mitochondrial dynamics are supposed to have...

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