Article
Association of HLA-G 3'UTR polymorphisms and haplotypes with severe sepsis in a Brazilian population.
Human immunology - 1 Nov 2017
Hahn Eriza Cristina, Zambra Francis Maria Báo, Kamada Anselmo Jiro, Delongui Francieli, Grion Cíntia Magalhães Carvalho, Reiche Edna Maria Vissoci, Chies José Artur Bogo
Abstract excerpt
BACKGROUND: The human leukocyte antigen G (HLA-G) is a molecule involved in immune system modulation, acting in the maintenance of a state of immune tolerance. Some polymorphisms in the HLA-G gene 3' untranslated region (3'UTR) were associated to distinct levels of HLA-G expression and to sepsis development. In the present study, haplotypes and polymorphisms of the HLA-G 3'UTR were analyzed in Brazilian septic...
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