Article

Loss of piR-hsa-7221 regulation drives the expression of the LINE1-derived oncogenic lncRNA CASC9 in testicular cancer

2026-02-17

Abstract excerpt

Testicular germ cell tumours (TGCTs) are the most common cancer in young males and are considered curable if they respond to platinum-based therapy. However, a significant number of refractory patients develop metastatic disease and the lack targeted therapy remains an unmet clinical need. To identify novel therapeutic targets, we investigated the epigenetic instability of TGCTs and characterised novel oncogenic g...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a7813ea7-c25f-55dc-a9de-fe2642ca1e04
DOI: 10.64898/2026.02.14.705912

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of piR-hsa-7221 regulation drives the expression of the LINE1-derived oncogenic lncRNA CASC9 in testicular cancerDOI 10.64898/2026.02.14.705912Read

Critical Roles of PIWIL1 in Human Tumors: Expression, Functions, Mechanisms, and Potential Clinical ImplicationsSemantic proximity Read

A short PIWIL2 isoform PL2L60A induces functional and transcriptional changes indicative of a procancerous phenotype.Semantic proximity Read

Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertilitySemantic proximity Read

PIWI-interacting RNA 021285 is involved in breast tumorigenesis possibly by remodeling the cancer epigenome.Semantic proximity Read

piRNA pathway targets active LINE1 elements to establish the repressive H3K9me3 mark in germ cells.Semantic proximity Read

Multiple transcriptome analysis of Piwil2-induced cancer stem cells, including piRNAs, mRNAs and miRNAs reveals the mechanism of tumorigenesis and developmentSemantic proximity Read

PIWIL2 downregulation in colon cancer promotes transposon activity and pro-tumorigenic phenotypesSemantic proximity Read

piRNAs and PIWI proteins as potential biomarkers in ‌Breast cancerSemantic proximity Read

Acute testicular hyperthermia leads to a rapid loss of global piRNA levels and a consequent increase in transcript abundance, including LINE1 activity within heat-sensitive male germ cellsSemantic proximity Read

PIWIL2 downregulation in colon cancer promotes transposon activity and pro-tumorigenic phenotypes.Semantic proximity Read

Pachytene piRNAs define a conserved program of meiotic gene regulationSemantic proximity Read

[Carcinoma in situ of the testis: predisposition, evolution and early detection].Semantic proximity Read