Article
Acute testicular hyperthermia leads to a rapid loss of global piRNA levels and a consequent increase in transcript abundance, including LINE1 activity within heat-sensitive male germ cells
2025-03-31
Abstract excerpt
<h4>Objective</h4> To understand the immediate impact that testicular heat stress has on isolated populations of precursor male germ cells including Spermatocytes and Spermatids. <h4>Design</h4> Mice were given testicular heat stress and pre-cursor male germ cells were immediately isolated. RNA sequencing was performed and validated using qPCR. <h4>Subjects</h4> This work was carried out in adult male CD1 mice....
Topics
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- Climate Change and Health Impacts
- Dietary Effects on Health
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- MicroRNA in disease regulation
- Reproductive Biology and Fertility
- RNA Interference and Gene Delivery
- Sperm and Testicular Function
- Xenotransplantation and immune response
Identifiers and source
- Literature Corpus work
- 649ce5b8-93a9-5240-8ae2-0cc19b3f1189
- DOI
- 10.1101/2025.03.30.646213
