Molecular glues that inhibit deubiquitylase activity and inflammatory signalling

Abstract excerpt

Deubiquitylases (DUBs) are crucial in cell signalling and are often regulated by interactions within protein complexes. The BRCC36 isopeptidase complex (BRISC) regulates inflammatory signalling by cleaving K63-linked polyubiquitin chains on Type I interferon receptors (IFNAR1). As a Zn 2+ -dependent JAMM/MPN DUB, BRCC36 is challenging to target with selective inhibitors. We discovered first-in-class inhibitors, t...

Topics

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• Acute Myeloid Leukemia Research
• Calcium-Binding Proteins
• CRISPR and Genetic Engineering
• Epitopes
• interferon and immune responses
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

a77c8802-680b-546f-bd11-5c7835c89a2b

DOI

10.1101/2024.09.07.611787