Article

A novel HERC4-dependent glue degrader targeting STING

2023-02-08

Abstract excerpt

Stimulator of interferon genes (STING) is a central component of the pathway sensing the presence of cytosolic nucleic acids, having a key role in type I interferon innate immune response. Localized at the endoplasmic reticulum (ER), STING becomes activated by cGAMP, which is generated by the intracellular DNA sensor cyclic GMP-AMP synthase (cGAS). Due to its critical role in physiological function and its ‘ invol...

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Literature Corpus work: 6a1c0374-36bf-5399-8daf-b17480cca757
DOI: 10.1101/2023.02.08.527642

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