Article

Expanding the <i>MECP2</i> network using comparative genomics reveals potential therapeutic targets for Rett syndrome

2021-02-15

Abstract excerpt

Inactivating mutations in the Methyl-CpG Binding Protein 2 (MECP2) gene are the main cause of Rett syndrome (RTT). Despite extensive research into MECP2 function, no treatments for RTT are currently available. Here we use an evolutionary genomics approach to construct an unbiased MECP2 gene network, using 1,028 eukaryotic genomes to prioritize proteins with strong co-evolutionary signatures with MECP2. Focusing on...

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Literature Corpus work: a7772c8d-05f7-584a-abab-c1f89a8e0863
DOI: 10.1101/2021.02.14.431162

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