Article

Suppressor mutations in <i>Mecp2</i> -null mice reveal that the DNA damage response is key to Rett syndrome pathology

2019-10-19

Abstract excerpt

Mutations in X-linked methyl-CpG-binding protein 2 ( MECP2) cause Rett syndrome (RTT). We carried out a genetic screen for secondary mutations that improved phenotypes in Mecp2 /Y mice after mutagenesis with N -ethyl- N -nitrosourea (ENU), aiming to identify potential therapeutic entry points. Here we report the isolation of 106 founder animals that show suppression of Mecp2 -null traits from screening 3,177...

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Literature Corpus work: 4fa9d01b-c4e8-51aa-8678-565eb4476e5b
DOI: 10.1101/810929

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