Article

An unconventional HxD motif orchestrates coatomer-dependent coronavirus morphogenesis

2025-10-17

Abstract excerpt

<h4>ABSTRACT</h4> Assembly of infectious coronaviruses requires spike (S) protein trafficking by host coatomer, typically via a dibasic signal in the S cytoplasmic tail. However, the human embecoviruses HKU1 and OC43, as well as the model virus MHV, lack this motif. Here we identify a conserved His-x-Asp (HxD) sequence that functions as an unconventional coatomer-binding signal. Structural and biochemical analyse...

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Literature Corpus work: a75f27b2-57af-51f9-a5df-e6da02510fc6
DOI: 10.1101/2025.10.16.682669

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